This article is from BMC Veterinary Research , volume 9 . Abstract Background: The bile salt export pump (BSEP/ABCB11) is the primary transporter for the excretion of bile acids from hepatocytes into bile. In human, inhibition of BSEP by drugs has been related to drug-induced cholestasis and subsequent cytotoxic effects. The role of BSEP in canine and feline liver diseases has not been studied in detail, but the same mechanism of inhibition by drugs as in humans could play a role in veterinary...
Source: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3900472